These are intentionally broad and there are smaller problems within these interests (or "missions") that could be successful businesses. My thought process isn't necessarily to only work on things that exactly fit into one or more of these buckets. The first goal would be to make something people want.

Help people work and succeed in the technology industry

Help create a world where a distributed workforce is the norm.

Help create a world with affordable, higher outcome alternatives to traditional universities.

Help creators to earn a living doing what they love.

Help create immersive educational or entertaining experiences using VR or AR.

Help people solve problems without having to learn how to code.